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KMID : 0360319870190020057
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Journal of Korean Cancer Research Association
1987 Volume.19 No. 2 p.57 ~ p.62
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Immunological Studies on the Antitumor Component of Lyophyllum decastes (II)
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李廷玉/Lee, Chong Ock
崔應七/金炳珏/Choi, Eung Chil/Kim, Byong Kak
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Abstract
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Lyophyllan A was isolated as an antitumor component from Lyophyllum decastes. To elucidate mechanisms of its antitumor activity, its effects on immune response were examined. Lyophyllan A restored the suppressed delayed-type hypersensitivity reaction in tumor-bearing mice up to 85. 7% of the normal level. Also lyophyllan A enhanced in vivo generation of cytotoxic T-lymphocytes. When effects of lyophyllan A on natural killer cells that are one of the important nonspecific effector cells were examined, it augmented natural killer activity in the spleen cells of mice. These results showed that lyophyllan A is an immunopotentiator.
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